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THE USE OF LOW ENERGY PHOTON THERAPY (LEPT) IN VENOUS LEG ULCERS: A DOUBLE BLIND, PLACEBOCONTROLLED STUDY Adltya K.
Gupta, MD, FRCP(C)), Natalia Filonenko, PhD, Norman Salansky, PhD, flms, Daniel
N. Sadder, MD, FRCP(C) BACKGROUND.
Venous ulcers are estimated to be present in 0.2 to 0.4% of the population.
Although new therapies have significant promise, nonhealing ulcers still
represent a significant problem. Objective. To evaluate the efficacy of low
energy photon therapy (LEPT) in the treatment of venous leg ulcers. METHODS. A
placebo-controlled, double-blind study using low energy photon therapy was
performed in nine patients with 12 venous ulcers. Treatment was given three
times a week for 10 weeks, using two monochromatic optical sources. One source
provided a wavelength (A) of 660 nm (red) while the second source delivered a
wavelength of 880 nm (infrared). Two optical probes were used, one consisted of
an array of 22 monochromatic sources, operating at a wavelength of 660 nm and
covering an area 6 x 10 cm2. The second probe had seven infrared sources,
operating at a wavelength of 880 nm and covering an area of 4 cm2 The above
configuration of optical probes was selected to cover the majority of the ulcer
area being treated. The patients who were randomized to placebo treatment
received sham therapy from an identical-appearing light source from the same
delivery system. RESULTS. Nine
patients with 12 venous ulcers were randomized to receive LEPT or placebo
therapy. At the conclusion of the study, the percentage of the initial ulcer
area remaining unhealed in the LEPT and placebo groups was 24.4% and 84.7%,
respectively (P = 0.0008). The decrease in ulcer area (compared to baseline)
observed in the LEPT and placebo groups was 193.0 mm2 and 14.7 222, respectively
(P = 0.0002). One patient dropped out of the study, complaining of lack of
treatment efficacy; he was found to be randomized to the placebo group. There
were no adverse effects. CONCLUSION.
In this placebo-controlled, double-blind study LEPT was an effective modality
for the treatment of venous leg ulcers. © 1998 by the American Society for
Dermatologic Surgery, Inc. Dermatol Surg 1998;24:1383-1386. From the Division of
Dermatology, Department of Medicine, University of Toronto; International
Medical Instruments Inc.; and Selye-Toffler University, Toronto, Ontario,
Canada. © 1998 by the American Society for Dermatologic Surgery, Inc. - Published by Elsevier Science Inc. 1076-0512/98/$19.00 - PII S1076-0512(98)00168-X |
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